Article date: 1990/2/19
PubMed ID: 1691040
Journal name: Brain research (ISSN: 0006-8993)
Microinjections of the substance P (SP) antagonist (D-pro2,D-phe7,D-trp9)-SP, or the gamma-aminobutyric acid (GABA) agonist, muscimol, into the entopeduncular nucleus reduced muscle tone in genetically spastic rats in a dose- and time-dependent manner. Similar injections into the ventral thalamus, zona incerta or amygdala had no effect on muscle tone. The muscle relaxant effect of (D-pro2,D-phe7,D-trp9)-SP injected into the entopeduncular nucleus was blocked by co-injections of SP, and that of muscimol by the GABAA antagonist, bicuculline methiodide. These results suggest that SP- and GABA-dependent mechanisms in the entopeduncular nucleus mediate regulation of the muscle tone.
Author List: Turski L, Klockgether T, Turski W A, Schwartz M, Sontag K H
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Muscimol; Substance P; gamma-Aminobutyric Acid; substance P, Pro(2)-Phe(7)-Trp(9)-;
Mesh terms: Animals; Female; Globus Pallidus/drug effects; Male; Muscimol/pharmacology; Muscle Spasticity/physiopathology; Muscle Tonus/drug effects; Rats; Rats, Inbred Strains; Substance P/analogs & derivatives; gamma-Aminobutyric Acid/metabolism;