Autoradiographic localization of [3H]muscimol binding sites in rat stomach: evidence for mucosal GABAA receptors.

Article date: 1990/1/17

PubMed ID: 1691102

Journal name: European journal of pharmacology (ISSN: 0014-2999)


The distribution in the rat stomach of specific [3H]muscimol binding sites, which show characteristics of GABAA receptors, was examined by light microscopic autoradiography. Silver grains representing specific binding were present both in the antrum and body, with highest densities in the muscle layers. A small fraction of the binding was confined to gland cells of the mucosa in the gastric body, rather than in the antrum. The label was not specifically concentrated at the myenteric ganglia. These findings, along with earlier data, suggests that the local GABA content may regulate not only the contractility, but also the secretory functions of the stomach via gastric GABAA receptors.

This document is available from: http://directlinks.cc/files/muscimol/1691102.pdf

Author List: Erdö S L, De Vincentis G, Amenta F

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Receptors, GABA-A; Muscimol; Silver;

Mesh terms: Animals; Autoradiography; Male; Muscimol/metabolism; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; Silver; Staining and Labeling; Stomach/metabolism;

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