Subregions of the caudate nucleus and their in- and output channels in oro-facial dyskinesia: a behavioural and retrograde tracing study in the cat.

Article date: 1991/1/18

PubMed ID: 1707740

Journal name: Brain research (ISSN: 0006-8993)


Previous studies have shown that the feline caudate nucleus contains DPI-sensitive (caput nuclei caudati, anterodorsal part; r-CRM) and DPI-insensitive (caput nuclei caudati, rostromedial part; CRM) regions. Stimulation of dopamine receptors within the r-CRM by dopamine or DPI are known to elicit oro-facial dyskinesia (OFD), i.e. a syndrome of tic-like contractions of the facial muscles in combination with tongue protrusions. OFD is also elicited from the sub-commissural part of the globus pallidus (scGP), a first order output station of the r-CRM, but not from the CRM. On the basis of these data it has been hypothesized that (1) OFD is a specific feature of the r-CRM, but not the CRM; (2) effects elicited from the r-CRM are funneled via the scGP, and that (3) r-CRM and CRM are differentially innervated. Cats were bilaterally equipped with cannulas directed at the CRM or r-CRM and scGP. Following recovery from the operation the cats received bilateral injections of DPI into CRM (5 micrograms/5 microliter) or r-CRM (5 and 10 micrograms/5 microliter), the latter in combination with muscimol (50 and 100 ng/1 microliter) into the scGP or its solvent. Subsequently, behaviour was analyzed. OFD, quantified in number of tongue protrusions, was only elicited from the r-CRM, but not from the CRM confirming previously reported data in this respect. Furthermore the effect varied according to the dose used. The OFD elicited from the r-CRM was found to be blocked at the level of the scGP by local injections of muscimol, a GABA agonist.(ABSTRACT TRUNCATED AT 250 WORDS)

This document is available from: http://directlinks.cc/files/muscimol/1707740.pdf

Author List: Spooren W P, Groenewegen H J, Cools A R

Publication Types: Journal Article

Substances mentioned in the article: Catecholamines; Dopamine Agents; Imidazolines; Receptors, Dopamine; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins; Picrotoxin; Muscimol; Carbachol; (3,4-dihydroxyphenylamino)-2-imidazoline; Horseradish Peroxidase;

Mesh terms: Animals; Axonal Transport; Carbachol/pharmacology; Catecholamines/pharmacology; Cats; Caudate Nucleus/anatomy & histology; Dopamine Agents/pharmacology; Facial Muscles/innervation; Horseradish Peroxidase; Imidazolines; Male; Models, Neurological; Movement Disorders/physiopathology; Muscimol/pharmacology; Picrotoxin/pharmacology; Receptors, Dopamine/drug effects; Syndrome; Tic Disorders/physiopathology; Tongue/innervation; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins;

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