Lesions of nucleus basalis alter ChAT activity and EEG in rat frontal neocortex.

Article date: 1991/7/1

PubMed ID: 1713553

Journal name: Electroencephalography and clinical neurophysiology (ISSN: 0013-4694)


The EEG was recorded from frontal, parietal and visual cortices of sham-operated control rats and rats having ibotenic acid lesions of the nucleus basalis. Recordings were made during a period of rest and during stimulus-evoked desynchronization. Spectral power was determined using a Fast Fourier Transform routine; 3 artifact-free 4 sec epochs of resting activity and two 4 sec epochs of activated EEG were analyzed. Choline acetyltransferase activity (ChAT) was measured in each cortical area and was reduced in lesioned animals an average of 25% in frontal cortex, 19% in the parietal region and 10% in visual cortex. The percent of low frequency activity (1-12 Hz) in the frontal EEG was significantly greater in lesioned animals than in the control group during quiet rest; a significant correlation was found between ChAT activity and power in this band. Desynchronized activity was largely unaffected except for a reduction in 25-31 Hz activity in the frontal cortex of lesioned animals. EEG activity in both the parietal and visual areas was unchanged from control values.

Author List: Ray P G, Jackson W J

Publication Types: Comparative Study; Journal Article

Substances mentioned in the article: Ibotenic Acid; Choline O-Acetyltransferase;

Mesh terms: Animals; Brain Diseases/chemically induced; Cerebral Cortex/enzymology; Choline O-Acetyltransferase/analysis; Cortical Synchronization; Electroencephalography; Fourier Analysis; Ibotenic Acid; Male; Olivary Nucleus/physiopathology; Rats; Rats, Inbred Strains;

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