1714302

Analysis of an experimental cortical network: II). Connections of visual areas 17 and 18 after neonatal injections of ibotenic acid.

Article date: 1991/1/1

PubMed ID: 1714302

Journal name: Journal of neural transplantation & plasticity (ISSN: 0792-8483)

ABSTRACT

Lesions of cortical areas 17 and 18 were produced in newborn kittens by local injections of the excitotoxin ibotenic acid. In the adult this results in a microcortex which consists of superficial layers I, II and III, in the absence of granular and infragranular layers. Horseradish peroxidase, alone or wheat germ agglutinin conjugated, was injected in the microcortex or in the contralateral, intact areas 17 and 18. The microcortex maintains several connections characteristic of normal areas 17 and 18 of the cat. It receives afferents from the dLGN, and several visual areas of the ipsilateral and contralateral hemisphere. However, it has lost its projections to dLGN, superior colliculus, and, at least in part, those to contralateral visual areas. Thus some parts of the microcortex receive from, but do not project into, the corpus callosum. In addition, the microcortex maintains afferents from ipsilateral and contralateral auditory areas AI and AII which are normally eliminated in development.

This document is available from: http://directlinks.cc/files/muscimol/1714302.pdf

Author List: Innocenti G M, Berbel P

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins; Ibotenic Acid; Horseradish Peroxidase;

Mesh terms: Animals; Animals, Newborn/physiology; Cats; Corpus Callosum/pathology; Histocytochemistry; Horseradish Peroxidase; Ibotenic Acid/toxicity; Neural Pathways/cytology; Neurons, Afferent/physiology; Visual Cortex/cytology; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins;

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