1723526

Dorsal hippocampal lesion abolishes the response to FG-7142 in the rat.

Article date: 1991/9/1

PubMed ID: 1723526

Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)

ABSTRACT

The effects of the anxiogenic beta-carboline FG-7142 (15 mg/kg IP) on exploratory locomotor activity were assessed in rats with sham or ibotenic acid (IA) lesions of the dorsal or ventral hippocampus. FG-7142 reduced exploratory activity similarly in control animals as well as in those with IA lesions of the ventral hippocampus. In contrast, FG-7142 had no effect on rats with dorsal hippocampal lesions. The results suggest that the dorsal hippocampus plays a unique role in FG-7142-mediated attenuation of locomotor exploration. Other studies suggest that serotonergic systems may mediate these properties of FG-7142.

Author List: Lipska B K, Jaskiw G E, Weinberger D R

Publication Types: Journal Article

Substances mentioned in the article: Carbolines; Ibotenic Acid; FG 7142;

Mesh terms: Animals; Carbolines/pharmacology; Exploratory Behavior/drug effects; Hippocampus/anatomy & histology; Ibotenic Acid/toxicity; Male; Rats; Rats, Inbred Strains; Staining and Labeling;

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