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17436 [2018/11/20 14:26] (current)
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 +====== The turnover rate of gamma-aminobutyric acid in the nuclei of telencephalon:​ implications in the pharmacology of antipsychotics and of a minor tranquilizer.======
 +
 +** Article date:** 1977/6/1
 +~~META:date created = 1977-06-01~~
 +
 +** PubMed ID: 17436 **
 +
 +** Journal name: Biological psychiatry (ISSN: 0006-3223) **
 +
 +** ABSTRACT **
 +
 +The turnover rate of GABA is measured in substantia nigra, globus pallidus, N. accumbens, and striatum of rats injected with muscimol, a potent GABA agonist, and diazepam. The similarity of action of the two drugs on GABA turnover further supports the theory that diazepam acts as a GABA-mimetic drug. Haloperidol and clozapine affect GABA turnover differently in different nuclei. Haloperidol decreases GABA turnover in caudate but does not affect that in substantia nigra, whereas clozapine increases GABA turnover in both areas. However, both drugs accelerate GABA turnover in globus pallidus and N. accumbens. It is suggested that an increase of GABA turnover and perhaps of GABA release in striatum and substantia nigra may account for the lack of tardive dyskinesia and extrapyramidal side effects of clozapine.
 +
 +===== ===== 
 +
 +Author List: Mao C C, Marco E, Revuelta A, Bertilsson L, Costa E
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Aminobutyrates;​ Anti-Anxiety Agents; Antipsychotic Agents; Glutamates; Parasympathomimetics;​ gamma-Aminobutyric Acid; Clozapine; Haloperidol;​ Diazepam; ​
 +
 +Mesh terms: Aminobutyrates/​metabolism;​ Animals; Anti-Anxiety Agents/​pharmacology;​ Antipsychotic Agents/​pharmacology;​ Caudate Nucleus/​metabolism;​ Clozapine/​pharmacology;​ Corpus Striatum/​metabolism;​ Diazepam/​pharmacology;​ Globus Pallidus/​metabolism;​ Glutamates/​metabolism;​ Haloperidol/​pharmacology;​ Male; Parasympathomimetics/​pharmacology;​ Rats; Substantia Nigra/​metabolism;​ Telencephalon/​metabolism;​ gamma-Aminobutyric Acid/​metabolism; ​
 +
 +{{tag> Diazepam Glutamates Aminobutyrates gamma-Aminobutyric_Acid Anti-Anxiety_Agents Clozapine Haloperidol Parasympathomimetics Antipsychotic_Agents }}
 +
 +{{keywords>​ Diazepam, Glutamates, Aminobutyrates,​ gamma-Aminobutyric Acid, Anti-Anxiety Agents, Clozapine, Haloperidol,​ Parasympathomimetics,​ Antipsychotic Agents}}
 +
  
17436.txt ยท Last modified: 2018/11/20 14:26 (external edit)