NGF increases cortical acetylcholine release in rats with lesions of the nucleus basalis.

Article date: 1991/10/1

PubMed ID: 1756238

Journal name: Neuroreport (ISSN: 0959-4965)


Rats received a unilateral lesion of the nucleus basalis by infusion of ibotenic acid. Two weeks after the lesion, osmotic minipumps were implanted, that infused 1 microgram human recombinant nerve growth factor (NGF) or cytochrome-C per day into the lateral ventricle. After four weeks of treatment, release of acetylcholine was measured in the frontal neocortex by means of in-vivo microdialysis. Release was decreased by 75% on the lesioned side; perfusion with 100 mM KCl increased release on the intact side by 130% and on the lesioned side by 80%. Treatment with NGF increased release on the lesioned side twofold, but had no effect on release on the intact side.

Author List: Dekker A J, Langdon D J, Gage F H, Thal L J

Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Nerve Growth Factors; Recombinant Proteins; Potassium Chloride; Choline O-Acetyltransferase; Choline; Acetylcholine;

Mesh terms: Acetylcholine/metabolism; Animals; Cerebral Cortex/drug effects; Choline/metabolism; Choline O-Acetyltransferase/metabolism; Dialysis/methods; Functional Laterality; Hippocampus/drug effects; Male; Nerve Growth Factors/pharmacology; Parietal Lobe/drug effects; Potassium Chloride/pharmacology; Rats; Rats, Inbred F344; Recombinant Proteins/pharmacology; Substantia Innominata/physiology;

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