1765584

Amygdala-dependent and amygdala-independent pathways for contextual fear conditioning.

Article date: 2007/6/26

PubMed ID: 1765584

Journal name: Neuroscience (ISSN: 0306-4522)

ABSTRACT

The basolateral amygdala (BLA), consisting of the lateral and basal nuclei, is considered to be essential for fear learning. Using a temporary inactivation technique, we found that rats could acquire a context-specific long-term fear memory without the BLA but only if intensive overtraining was used. BLA-inactivated rats' learning curves were characterized by slow learning that eventually achieved the same asymptotic performance as rats with the BLA functional. BLA inactivation abolished expression of overtrained fear when rats were overtrained with a functional BLA. However, BLA-inactivation had no effect on the expression of fear in rats that learned while the BLA was inactivated. These data suggest that there are primary and alternate pathways capable of mediating fear. Normally, learning is dominated by the more efficient primary pathway, which prevents learning in the alternate pathway. However, alternate pathways compensate when the dominant pathway is compromised.

Author List: Ponnusamy R, Poulos A M, Fanselow M S

Publication Types: Journal Article; Research Support, N.I.H., Extramural

Article Date: 2007/06/22

Substances mentioned in the article: GABA Agonists; Muscimol;

Mesh terms: Amygdala/drug effects; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Classical/drug effects; Fear; Freezing Reaction, Cataleptic/drug effects; GABA Agonists/pharmacology; Male; Memory/drug effects; Muscimol/pharmacology; Neural Pathways/drug effects; Rats; Rats, Long-Evans;

Citations: - 2237784

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