Specificity of functional changes during normal brain aging.

Article date: 1991/1/1

PubMed ID: 1776764

Journal name: Annals of the New York Academy of Sciences (ISSN: 0077-8923)


Although there is no question that age-related alterations in neural function occur in the central nervous system (CNS) of mammals, these changes tend to be somewhat circumscribed rather than completely global, even in pathological conditions. Examples of this kind of specificity of functional neural change are drawn from experiments on the electrophysiology of the senescent rat hippocampus.

Author List: Barnes C A, Foster T C, Rao G, McNaughton B L

Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Ibotenic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

Mesh terms: Aging/physiology; Animals; Hippocampus/physiology; Ibotenic Acid/analogs & derivatives; Membrane Potentials/physiology; Neuronal Plasticity/physiology; Rats; Synapses/physiology; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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