Muscimol-associated changes in local cerebral glucose use following chronic diazepam administration.

Article date: 1991/9/6

PubMed ID: 1782545

Journal name: Brain research (ISSN: 0006-8993)


Local cerebral glucose use (LCGU) was determined in parallel groups of conscious rats receiving muscimol (1.5 mg/kg i.v.) after either saline pretreatment (28 days i.p.), saline pretreatment (27 days i.p.) followed by a single dose of diazepam (5 mg/kg i.p.) 24 h prior to muscimol administration, or chronic diazepam pretreatment (5 mg/kg i.p. daily for 28 days). Acute administration of muscimol produced a significant reduction in LCGU in 25 out of 66 structures examined compared with vehicle-treated controls. The pattern of reductions was heterogeneous. Thalamic and most cortical areas showed reductions of the order of 30-45%, whereas more modest depressions of 15-20% were observed in some limbic structures (e.g. basolateral amygdala, anterior thalamic nuclei, nucleus accumbens, subiculum). This contrasts with the more extensive and homogeneous pattern of LGCU reductions (around 20%) produced by diazepam. Neither acute diazepam treatment the previous day nor chronic diazepam pretreatment altered the LGCU response to muscimol. These data suggest that high-affinity GABA receptor-mediated responses are unchanged by both acute and chronic benzodiazepine pretreatment. It would appear unlikely that alterations in these responses contribute to the mechanism of benzodiazepine tolerance.

This document is available from: http://directlinks.cc/files/muscimol/1782545.pdf

Author List: Brett R R, Pratt J A

Publication Types: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Blood Glucose; Muscimol; Deoxyglucose; Glucose; Diazepam;

Mesh terms: Animals; Autoradiography; Behavior, Animal/drug effects; Blood Glucose/metabolism; Blood Pressure/drug effects; Brain Chemistry/drug effects; Deoxyglucose/blood; Depression, Chemical; Diazepam/pharmacology; Glucose/metabolism; Male; Muscimol/pharmacology; Rats;

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