Effects of chronic ethanol consumption associated or not with experimental anterior thalamic lesions on spontaneous sequential alternation in mice.

Article date: 1991/12/16

PubMed ID: 1815150

Journal name: Neuroscience letters (ISSN: 0304-3940)


Previous studies from our team have shown that a 12 month ethanol administration induced deficits in a sequential alternation task, whereas a 6 month treatment had no effects. We have already shown that the 12 month treatment induced deficits both in diencephalic and hippocampal structures, whereas the 6 month treatment damaged only the mammillary bodies. Thus, the question remained whether or not increasing selectively the diencephalic damage by lesioning the anterior thalamic nuclei would disrupt sequential alternation in 6 month ethanol-treated mice. Results indicate that alcohol-treated mice exhibiting experimental lesions into the anterior thalamus were significantly impaired in the sequential task as compared to both controls or 6 month ethanol-treated mice. In contrast, anterior thalamic lesions in normal (no alcohol treatment) subjects induced no deficits. The relative contribution of the hippocampo-mammillo-thalamic circuitry in sequential alternation is discussed.

Author List: Beracochea D, Jaffard R

Publication Types: Comparative Study; Journal Article

Substances mentioned in the article: Ibotenic Acid; Ethanol;

Mesh terms: Afferent Pathways/physiopathology; Alcoholism/physiopathology; Animals; Ethanol/pharmacology; Exploratory Behavior/drug effects; Hippocampus/drug effects; Ibotenic Acid/toxicity; Mammillary Bodies/drug effects; Mice; Spatial Behavior; Thalamus/drug effects; Time Factors;

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