Pedunculopontine stimulation from primate to patient.

Article date: 2012/1/26

PubMed ID: 1821843

Journal name: Journal of neural transmission (Vienna, Austria : 1996) (ISSN: 1435-1463)

DOI: 10.1007/s00702-011-0631-8


Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.

Author List: Pereira Erlick A C, Nandi Dipankar, Jenkinson Ned, Stein John F, Green Alexander L, Aziz Tipu Z

Publication Types: Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review

Article Date: 2011/03/30

Substances mentioned in the article: Convulsants; GABA-A Receptor Agonists; Muscimol; Bicuculline;

Mesh terms: Animals; Bicuculline/pharmacology; Biophysics; Convulsants/pharmacology; Deep Brain Stimulation/history; Disease Models, Animal; GABA-A Receptor Agonists/therapeutic use; History, 20th Century; Humans; Macaca; Male; Muscimol/therapeutic use; Parkinson Disease/etiology; Pedunculopontine Tegmental Nucleus/physiology;

Citations: - 1727169

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