Molecular cloning and characterization of the rat NMDA receptor.

Article date: 1991/11/7

PubMed ID: 1834948

Journal name: Nature (ISSN: 0028-0836)


A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.

Author List: Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N, Nakanishi S

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: RNA, Messenger; Receptors, N-Methyl-D-Aspartate; Ibotenic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Kainic Acid;

Mesh terms: Amino Acid Sequence; Animals; Base Sequence; Brain/metabolism; Cloning, Molecular; Electrophysiology; Ibotenic Acid/analogs & derivatives; Kainic Acid/chemistry; Molecular Sequence Data; Molecular Structure; RNA, Messenger/analysis; Rats; Receptors, N-Methyl-D-Aspartate/genetics; Xenopus/genetics; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

Citations: - Molecular cloning and characterization of the rat NMDA receptor.

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