GABAA and GABAB receptors modulate the K(+)-evoked release of sensory CGRP from the guinea pig urinary bladder.

Article date: 1991/1/1

PubMed ID: 1849214

Journal name: Life sciences (ISSN: 0024-3205)


Superfusion of mucosa-free muscle slices of guinea-pig urinary bladder with 40 mM K+ produced a remarkable increase in calcitonin gene-related peptide-like immunoreactivity (CGRP-LI), that in this organ is entirely contained in capsaicin-sensitive nerves. GABA (1 mM) did neither affect the basal nor the 40 mM K+ evoked CGRP-LI release. Baclofen (0.1 mM) or muscimol (1 mM) did not affect the basal CGRP-LI outflow. However, baclofen (0.1 mM) significantly reduced by 32% and muscimol (0.1-1 mM) significantly increased by 60% and 70%, respectively the K(+)-evoked CGRP-LI release. These findings add neurochemical evidence to the functional data suggesting the existence of GABAA and GABAB receptors which modulate the efferent function of capsaicin-sensitive afferents.

This document is available from: http://directlinks.cc/files/muscimol/1849214.pdf

Author List: Santicioli P, Tramontana M, Del Bianco E, Maggi C A, Geppetti P

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Receptors, GABA-A; Muscimol; Calcitonin Gene-Related Peptide; Baclofen; Potassium;

Mesh terms: Animals; Baclofen/pharmacology; Calcitonin Gene-Related Peptide/metabolism; Female; Guinea Pigs; In Vitro Techniques; Male; Muscimol/pharmacology; Potassium/physiology; Receptors, GABA-A/classification; Urinary Bladder/physiology;

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