Neonatal striatal NADPH-diaphorase neurons are vulnerable to quisqualate and its analogue alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionate (AMPA).

Article date: 1991/5/13

PubMed ID: 1866084

Journal name: Neuroscience letters (ISSN: 0304-3940)


A small population of neurons in the mammalian striatum and cerebral cortex contain NADPH-diaphorase. Recently, this class of neurons has been found in vitro to be selectively vulnerable to low concentrations of non-N-methyl-D-aspartate (NMDA) glutamate agonists. To determine if this pattern exists in vivo, we injected either quisqualate (QA) or its inotropic site analogue alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionate (AMPA) into the striatum of neonatal rat pups and found a dose-dependent loss of NADPH-diaphorase reactive neurons. These data suggest that the QA receptor may be present and functional at postnatal day 7 when other glutamate receptor subtypes have not yet fully developed and that QA is working through its inotropic site since AMPA causes the same dose-dependent cell death.

Author List: Ferriero D M, Simon R P

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Neurotoxins; Ibotenic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Quisqualic Acid; NADPH Dehydrogenase;

Mesh terms: Animals; Animals, Newborn; Corpus Striatum/drug effects; Functional Laterality; Ibotenic Acid/analogs & derivatives; NADPH Dehydrogenase/metabolism; Neurons/drug effects; Neurotoxins/toxicity; Quisqualic Acid/toxicity; Rats; Rats, Inbred Strains; Reference Values; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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