1874821

Choline acetyltransferase activity associated with cerebral cortical microvessels does not originate in basal forebrain neurons.

Article date: 1991/9/1

PubMed ID: 1874821

Journal name: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (ISSN: 0271-678X)

ABSTRACT

Cerebral cortical microvessels are innervated by cholinergic fibers that are probably involved in the regulation of local cerebral blood flow and blood-brain barrier permeability. The possibility exists that the cholinergic terminals associated with the cortical microvasculature belong to neurons from the nucleus basalis magnocellularis (NBM), where 70% of the cortical cholinergic projections originate. To test this hypothesis, ibotenic acid (25 nmol) was injected unilaterally in the NBM in rats, and 14 days later, choline acetyltransferase (ChAT) activity was measured in the frontoparietal cortex and in a blood vessel fraction isolated from this region. Lesions of the NBM resulted in a 50% decrease of cortical ChAT as compared with control or sham-operated hemispheres; however, no changes were observed in the ChAT activity associated with cortical microvessels. These results indicate that, in rat cerebral cortex, the perivascular cholinergic terminals do not originate in the basal forebrain.

Author List: Galea E, Fern√°ndez-Shaw C, Triguero D, Estrada C

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Choline O-Acetyltransferase;

Mesh terms: Animals; Basal Ganglia/enzymology; Capillaries/enzymology; Cerebral Cortex/blood supply; Choline O-Acetyltransferase/metabolism; Male; Neurons/enzymology; Rats; Rats, Inbred Strains;

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