Isoguvacine, isonipecotic acid, muscimol and N-methyl isoguvacine on the GABA receptor in rat sympathetic ganglia.

Article date: 1978/9/15

PubMed ID: 191147

Journal name: Experientia (ISSN: 0014-4754)


The GABA-mimetic activities of 4 analogues muscimol, isonipecotic acid, isoguvacine and N-methyl isoguvacine have been examined at the GABA receptor in the rat isolated superior cervical ganglion. The depolarizing action of all 4 analogues could be selectively antagonized by bicuculline methochloride and isopropyl bicyclophosphate. Muscimol was the only analogue more potent than GABA (molar potency ratio = 5.08 +/- 0.707). The potency of isoguvacine was 0.23 +/- 0.026 and isonipecotic acid 0.011 +/- 0.0028. N-methyl isoguvacine was less than 0.001 GABA.

Author List: Bowery N G, Collins J F, Hudson A L, Neal M J

Publication Types: Journal Article

Substances mentioned in the article: Isonicotinic Acids; Isonipecotic Acids; Receptors, Neurotransmitter; Muscimol; gamma-Aminobutyric Acid;

Mesh terms: Animals; Dose-Response Relationship, Drug; Ganglia, Autonomic/drug effects; Isonicotinic Acids/pharmacology; Isonipecotic Acids/pharmacology; Membrane Potentials/drug effects; Muscimol/pharmacology; Rats; Receptors, Neurotransmitter/drug effects; Structure-Activity Relationship; gamma-Aminobutyric Acid/metabolism;

Citations: - 187950

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