191147

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191147 [2018/11/20 14:26] (current)
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 +====== Isoguvacine,​ isonipecotic acid, muscimol and N-methyl isoguvacine on the GABA receptor in rat sympathetic ganglia.======
 +
 +** Article date:** 1978/9/15
 +~~META:date created = 1978-09-15~~
 +
 +** PubMed ID: 191147 **
 +
 +** Journal name: Experientia (ISSN: 0014-4754) **
 +
 +** ABSTRACT **
 +
 +The GABA-mimetic activities of 4 analogues muscimol, isonipecotic acid, isoguvacine and N-methyl isoguvacine have been examined at the GABA receptor in the rat isolated superior cervical ganglion. The depolarizing action of all 4 analogues could be selectively antagonized by bicuculline methochloride and isopropyl bicyclophosphate. Muscimol was the only analogue more potent than GABA (molar potency ratio = 5.08 +/- 0.707). The potency of isoguvacine was 0.23 +/- 0.026 and isonipecotic acid 0.011 +/- 0.0028. N-methyl isoguvacine was less than 0.001 GABA.
 +
 +===== ===== 
 +
 +Author List: Bowery N G, Collins J F, Hudson A L, Neal M J
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Isonicotinic Acids; Isonipecotic Acids; Receptors, Neurotransmitter;​ Muscimol; gamma-Aminobutyric Acid; 
 +
 +Mesh terms: Animals; Dose-Response Relationship,​ Drug; Ganglia, Autonomic/​drug effects; Isonicotinic Acids/​pharmacology;​ Isonipecotic Acids/​pharmacology;​ Membrane Potentials/​drug effects; Muscimol/​pharmacology;​ Rats; Receptors, Neurotransmitter/​drug effects; Structure-Activity Relationship;​ gamma-Aminobutyric Acid/​metabolism; ​
 +
 +Citations: ​  - //​[[187950]]//​
 +  - //​[[5047849]]//​
 +  - //​[[1276543]]//​
 +  - //​[[1177140]]//​
 +  - //​[[196200]]//​
 +  - //​[[1142241]]//​
 +  - //​[[4730830]]//​
 +  - //​[[4154116]]//​
 +  - //​[[4505419]]//​
 +  - //​[[4625268]]//​
 +  - //​[[5711127]]//​
 +  - //​[[4398801]]//​
 +  - //​[[191147]]//​
 +
 +{{tag> Receptors,​_Neurotransmitter Isonicotinic_Acids gamma-Aminobutyric_Acid Muscimol Isonipecotic_Acids }}
 +
 +{{keywords>​ Receptors, Neurotransmitter,​ Isonicotinic Acids, gamma-Aminobutyric Acid, Muscimol, Isonipecotic Acids}}
 +
  
191147.txt · Last modified: 2018/11/20 14:26 (external edit)