[The formation of motor programs during pharmacological kindling].

Article date: 1990/10/1

PubMed ID: 1966093

Journal name: Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova (ISSN: 0015-329X)


In Wistar rats with the kindling phenomenon, the number of animals with three or more not stimulus-directed forms of swimming was increased. Obvious changes of swimming behaviour in these animals were also observed after intrastriatal injections of carbachol, apomorphine, haloperidol, muscimol and picrotoxin. These findings are discussed from the standpoint of a latent generator of pathologically enhanced excitation in the striatum which changed the ability of these rats to develop behavioral programs.

Author List: Shandra A A, Godlevskiĭ L S, Mazarati A M, Lobenko A A

Publication Types: Comparative Study; English Abstract; Journal Article

Substances mentioned in the article: Picrotoxin;

Mesh terms: Animals; Caudate Nucleus/drug effects; Dose-Response Relationship, Drug; Kindling, Neurologic/drug effects; Male; Motor Activity/drug effects; Physical Exertion/drug effects; Picrotoxin/pharmacology; Rats; Rats, Inbred Strains; Swimming;

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