Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate.

Article date: 1990/2/5

PubMed ID: 1969130

Journal name: Neuroscience letters (ISSN: 0304-3940)


Ibotenate and trans-D,L-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) are rigid analogues of glutamate. Ibotenate has been shown to activate phosphoinositide hydrolysis in rat brain slices. We now report that trans-ACPD also stimulates phosphoinositide hydrolysis but with much higher potency and efficacy than ibotenate. The pharmacological profiles, regional distributions, and developmental regulation of the responses to ibotenate and trans-ACPD are similar, suggesting that these agonists act at the same site. However, trans-ACPD is the first agonist described that is selective for this receptor relative to other excitatory amino acid receptor subtypes.

This document is available from: http://directlinks.cc/files/muscimol/1969130.pdf

Author List: Desai M A, Conn P J

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Amino Acids; Glutamates; Phosphatidylinositols; Cycloleucine; Ibotenic Acid; Glutamic Acid;

Mesh terms: Amino Acids/pharmacology; Animals; Cycloleucine/pharmacology; Glutamates/physiology; Glutamic Acid; Hippocampus/drug effects; Ibotenic Acid/pharmacology; In Vitro Techniques; Male; Phosphatidylinositols/metabolism; Rats; Rats, Inbred Strains;

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