Article date: 1990/4/10
PubMed ID: 1973101
Journal name: European journal of pharmacology (ISSN: 0014-2999)
The acid inhibitory properties of 3-amino-3-phenylpropionic acid, a structural GABA analogue, were studied in the perfused rat stomach preparation. 3-Amino-3-phenylpropionic acid, 10 and 30 mg/kg i.v., dose dependently suppressed the gastric acid secretion induced by baclofen (2 mg/kg s.c.). This secretagogue action had been shown to be unaffected by either GABAA or GABAB receptor antagonists. The i.v. administration of 3-amino-3-phenylpropionic acid (3 and 10 mg/kg) was also effective to abolish the acid stimulatory effects of muscimol (1 mg/kg i.v.) and 2-deoxy-D-glucose (200 mg/kg i.v.). 3-Amino-3-phenylpropionic acid, even at the high dose (30 mg/kg i.v.) had no influence on the acid output in response to histamine and bethanechol. Furthermore, 3-amino-3-phenylpropionic acid had no significant effect on the acid secretion induced by electrical vagal stimulation. These results indicate that the antisecretory effect of 3-amino-3-phenylpropionic acid is different from those of antimuscarinics, H2-receptor antagonists and vagal blockade. Together, the results suggest that 3-amino-3-phenylpropionic acid might act in the brain to inhibit central regulation mechanisms of gastric acid secretion, probably through GABA mechanisms.
Author List: Hara N, Natsume Y, Hara Y, Goto Y
Publication Types: Journal Article
Substances mentioned in the article: Bethanechol Compounds; Bethanechol; 3-amino-3-phenylpropionic acid; Muscimol; Phenylalanine; Atropine; Baclofen;
Mesh terms: Animals; Atropine/pharmacology; Baclofen/antagonists & inhibitors; Bethanechol; Bethanechol Compounds/pharmacology; Dose-Response Relationship, Drug; Electric Stimulation; Gastric Acid/metabolism; Gastric Mucosa/secretion; Male; Muscimol/pharmacology; Phenylalanine/analogs & derivatives; Rats; Rats, Inbred Strains; Stomach/drug effects; Vagus Nerve/physiology;