Further characterisation of excitatory amino acid receptors coupled to phosphoinositide metabolism in astrocytes.

Article date: 1990/6/8

PubMed ID: 1974335

Journal name: Neuroscience letters (ISSN: 0304-3940)


Excitatory amino acids stimulate phosphoinositide breakdown in astrocytes with the following rank order of effect: quisqualate greater than ibotenate = glutamate greater than kainate greater than N-methyl-D-aspartate. Quisqualate-induced responses were resistant to blockade with a range of receptor antagonists whereas those to glutamate were partially reversed by gamma-D-glutamylaminosulphonic acid and gamma-D-glutamylglycine. These antagonists were, however, more effective against kainate-stimulated phosphoinositide metabolism. These experiments together with those where combinations of agonists were used, suggest that the kainate-induced and, to some extent, the glutamate-induced responses were due to membrane depolarisation and that quisqualate activates a non-ionotropic class of receptor at which glutamate and ibotenate are partial agonists.

This document is available from: http://directlinks.cc/files/muscimol/1974335.pdf

Author List: Pearce B, Morrow C, Murphy S

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Glutamates; Neurotransmitter Agents; Oxadiazoles; Oxazoles; Phosphatidylinositols; Receptors, Amino Acid; Receptors, Cell Surface; Ibotenic Acid; Glutamic Acid; Quisqualic Acid;

Mesh terms: Astrocytes/cytology; Cells, Cultured; Glutamates/pharmacology; Glutamic Acid; Ibotenic Acid/pharmacology; Neurotransmitter Agents/pharmacology; Oxadiazoles/pharmacology; Oxazoles/pharmacology; Phosphatidylinositols/metabolism; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface/drug effects;

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