Article date: 1990/6/8
PubMed ID: 1974335
Journal name: Neuroscience letters (ISSN: 0304-3940)
Excitatory amino acids stimulate phosphoinositide breakdown in astrocytes with the following rank order of effect: quisqualate greater than ibotenate = glutamate greater than kainate greater than N-methyl-D-aspartate. Quisqualate-induced responses were resistant to blockade with a range of receptor antagonists whereas those to glutamate were partially reversed by gamma-D-glutamylaminosulphonic acid and gamma-D-glutamylglycine. These antagonists were, however, more effective against kainate-stimulated phosphoinositide metabolism. These experiments together with those where combinations of agonists were used, suggest that the kainate-induced and, to some extent, the glutamate-induced responses were due to membrane depolarisation and that quisqualate activates a non-ionotropic class of receptor at which glutamate and ibotenate are partial agonists.
Author List: Pearce B, Morrow C, Murphy S
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Glutamates; Neurotransmitter Agents; Oxadiazoles; Oxazoles; Phosphatidylinositols; Receptors, Amino Acid; Receptors, Cell Surface; Ibotenic Acid; Glutamic Acid; Quisqualic Acid;
Mesh terms: Astrocytes/cytology; Cells, Cultured; Glutamates/pharmacology; Glutamic Acid; Ibotenic Acid/pharmacology; Neurotransmitter Agents/pharmacology; Oxadiazoles/pharmacology; Oxazoles/pharmacology; Phosphatidylinositols/metabolism; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface/drug effects;