Receptor site specificity for the acute effects of beta-N-methylamino-alanine in mice.

Article date: 1990/10/2

PubMed ID: 1980247

Journal name: European journal of pharmacology (ISSN: 0014-2999)


DL-beta-N-methylamino-alanine (DL-BMAA; 1-10 mumol i.c.v.) in mice induced a syndrome of: ataxia, ptosis, scratching, jumping, myoclonic jerks, clonic muscle spasms and tonic seizure, which was unaffected by pretreatment with D(-)-4-(3-phosphonoprop-2-enyl)-piperazine-2-carboxylate (D(-)-CPPene; i.p.), or by co-administration of gamma-D-glutamylamino-methylsulphonate (gamma-D-GAMS with DL-BMAA; i.c.v.). Pretreatment with 1-(aminophenyl)-4-methyl-7,8-methylendioxy-5H-2,3-benzodiazepine (GYKI 52466; i.v.) decreased the incidence of clonic seizures for DL-BMAA, kainic acid and RS-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (RS-AMPA; i.c.v.). These results suggest an involvement of the AMPA/quisqualate subtype of excitatory amino acid receptors in acute BMAA toxicity.

Author List: Smith S E, Meldrum B S

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Amino Acids, Diamino; Anti-Anxiety Agents; Anticonvulsants; Organophosphorus Compounds; Piperazines; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Glutamine; GYKI 52466; beta-N-methylamino-L-alanine; Benzodiazepines; SDZ EAA 494; Ibotenic Acid; N-Methylaspartate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; gamma-glutamylaminomethylsulfonic acid; Kainic Acid;

Mesh terms: Amino Acids, Diamino/pharmacology; Animals; Anti-Anxiety Agents/pharmacology; Anticonvulsants/pharmacology; Behavior, Animal/drug effects; Benzodiazepines/pharmacology; Glutamine/analogs & derivatives; Ibotenic Acid/analogs & derivatives; Injections, Intraventricular; Kainic Acid/pharmacology; Kinetics; Male; Mice; N-Methylaspartate/pharmacology; Organophosphorus Compounds/pharmacology; Piperazines/pharmacology; Receptors, Drug/drug effects; Receptors, N-Methyl-D-Aspartate/drug effects; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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