Article date: 1991/5/1
PubMed ID: 2033505
Journal name: The Journal of pharmacology and experimental therapeutics (ISSN: 0022-3565)
Alzheimer's disease is characterized by the loss of cholinergic neurons in the nucleus basalis of Meynert and by a primary loss of memory function. Since staurosporine has been reported to induce differentiation in human neuroblastoma cells in vitro, we studied the effects of staurosporine on the amnesia induced by basal forebrain-lesion in rats. Staurosporine (0.05 and 0.1 mg/kg intraperitoneal) attenuated the impaired performance of water maze and passive avoidance tasks, even though the drug administration began 2 weeks after the lesion. Moreover, staurosporine (0.1 mg/kg) partially reversed the decrease of choline acetyltransferase activity in the fronto-parietal cortex induced by basal forebrain-lesion. These results suggest that staurosporine attenuates impairment of learning through reversal of damage to cholinergic neurons induced by basal forebrain-lesion. This evidence indicates that neurotrophic factor-like substances may be used in novel therapeutic approaches to Alzheimer's disease.
Author List: Nabeshima T, Ogawa S, Nishimura H, Fuji K, Kameyama T, Sasaki Y
Publication Types: Journal Article
Substances mentioned in the article: Alkaloids; Ibotenic Acid; Choline O-Acetyltransferase; Protein Kinase C; Staurosporine;
Mesh terms: Alkaloids/therapeutic use; Amnesia/chemically induced; Animals; Avoidance Learning/drug effects; Basal Ganglia/drug effects; Blood-Brain Barrier/drug effects; Choline O-Acetyltransferase/metabolism; Ibotenic Acid; Male; Protein Kinase C/antagonists & inhibitors; Rats; Rats, Inbred Strains; Staurosporine;