Article date: 1990/12/24
PubMed ID: 2085788
Journal name: Brain research (ISSN: 0006-8993)
The present study investigates whether the stimulation of gamma-aminobutyric acid (GABA)ergic system affects spatial navigation deficits induced by the lesioning of the nucleus basalis (NB). Thus, the effect of gamma-vinyl-GABA treatment which elevates the GABA levels in brain was studied on water maze task both in unoperated and NB-lesioned (ibotenic acid) rats. The subchronic administration of gamma-vinyl-GABA aggravated dose-dependently NB lesion-induced deficits, although it did not impair the performance of unoperated rats in this task. The imbalance between GABAergic system and cholinergic or non-cholinergic systems of the NB may contribute to spatial navigation deficits in rats.
Author List: Hannila T, Sirviö J, Riekkinen P J
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Aminocaproates; Ibotenic Acid; Vigabatrin;
Mesh terms: Aminocaproates/administration & dosage; Animals; Basal Ganglia/physiology; Dose-Response Relationship, Drug; Ibotenic Acid/pharmacology; Injections, Intraperitoneal; Male; Memory/physiology; Psychomotor Performance/physiology; Rats; Rats, Inbred Strains; Space Perception/physiology; Vigabatrin;