2085788

The effect of gamma-vinyl-GABA on the performance of nucleus basalis-lesioned rats in spatial navigation task.

Article date: 1990/12/24

PubMed ID: 2085788

Journal name: Brain research (ISSN: 0006-8993)

ABSTRACT

The present study investigates whether the stimulation of gamma-aminobutyric acid (GABA)ergic system affects spatial navigation deficits induced by the lesioning of the nucleus basalis (NB). Thus, the effect of gamma-vinyl-GABA treatment which elevates the GABA levels in brain was studied on water maze task both in unoperated and NB-lesioned (ibotenic acid) rats. The subchronic administration of gamma-vinyl-GABA aggravated dose-dependently NB lesion-induced deficits, although it did not impair the performance of unoperated rats in this task. The imbalance between GABAergic system and cholinergic or non-cholinergic systems of the NB may contribute to spatial navigation deficits in rats.

Author List: Hannila T, Sirviö J, Riekkinen P J

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Aminocaproates; Ibotenic Acid; Vigabatrin;

Mesh terms: Aminocaproates/administration & dosage; Animals; Basal Ganglia/physiology; Dose-Response Relationship, Drug; Ibotenic Acid/pharmacology; Injections, Intraperitoneal; Male; Memory/physiology; Psychomotor Performance/physiology; Rats; Rats, Inbred Strains; Space Perception/physiology; Vigabatrin;

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