Stimulated release of 3H-glycine from retina.

Article date: 1982/1/1

PubMed ID: 213815

Journal name: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (ISSN: 0721-832X)


The release of 3H-glycine was studied from rabbit retinas. Kainic acid (10(-5) M), a glutamate agonist, evoked prompt CA2+-dependent increased release of 3H-glycine. However, nuciferine (10(-4) M) could not suppress the effect of kainic acid. The effect of glutamic acid (10(-5) M) was significantly reduced in the presence of nuciferine (10(-4) M). The GABA analogues, muscimol and THIP, had no effect on the release of 3H-glycine. Aspartate and cystic acid were also without effect.

Author List: Bauer B

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Aporphines; Glutamates; Isoxazoles; Muscimol; Aspartic Acid; Glutamic Acid; Cysteic Acid; gaboxadol; Kainic Acid; Glycine; nuciferine;

Mesh terms: Animals; Aporphines/pharmacology; Aspartic Acid/pharmacology; Cysteic Acid/pharmacology; Glutamates/pharmacology; Glutamic Acid; Glycine/metabolism; In Vitro Techniques; Isoxazoles/pharmacology; Kainic Acid/pharmacology; Muscimol/pharmacology; Rabbits; Retina/metabolism;

Citations: - 7297619

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