Behavioral interactions between muscimol and compounds selective for the D1 and D2 dopamine receptor subtypes.

Article date: 1990/6/8

PubMed ID: 2143274

Journal name: Neuroscience letters (ISSN: 0304-3940)


The present study investigated the effects of the GABA agonist muscimol on the behaviors produced by acute injections of selective D1 and D2 agonists and antagonists. Muscimol potentiated the intensity of stereotyped behaviors shown by rats treated with the D2 agonist quinpirole; in contrast, it suppressed the repetitive bouts of grooming shown by rats treated with SKF38393. Muscimol potentiated the catalepsy produced by either a D1 (SCH23390) or D2 (metoclopramide) antagonist, suggesting that the cataleptic behaviors produced by these compounds may contain a common GABAergic mechanism.

This document is available from: http://directlinks.cc/files/muscimol/2143274.pdf

Author List: Asin K E, Bednarz L M

Publication Types: Journal Article

Substances mentioned in the article: Ergolines; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Quinpirole; Muscimol; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine;

Mesh terms: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology; Animals; Ergolines/pharmacology; Male; Muscimol/pharmacology; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine/drug effects; Receptors, Dopamine D1; Receptors, Dopamine D2; Stereotyped Behavior/drug effects;

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