Increase of GABA-stimulated diazepam binding after lipid methylation in membrane preparations from rat brain.

Article date: 1990/3/2

PubMed ID: 2158013

Journal name: Neuroscience letters (ISSN: 0304-3940)


Incubation of membrane preparations from rat brain with S-adenosyl-L-methionine resulted in methylation of the lipid fraction. Neither [3H]diazepam nor [3H]muscimol (a gamma-aminobutyric acid (GABA) agonist) binding was affected by this incubation. In contrast, when [3H]diazepam binding was stimulated by GABA, the methylation caused both a decrease of the minimal GABA concentration needed to produce its effect (10(-9) M instead of 10(-7) M) and an enhancement (from 36 to 66% over basal) of the GABA-stimulated [3H]diazepam binding.

This document is available from: http://directlinks.cc/files/muscimol/2158013.pdf

Author List: Benistant C, Rey C, Fonlupt P

Publication Types: Journal Article

Substances mentioned in the article: Membrane Lipids; Phospholipids; Receptors, GABA-A; gamma-Aminobutyric Acid; S-Adenosylmethionine; Diazepam;

Mesh terms: Animals; Brain/drug effects; Diazepam/metabolism; In Vitro Techniques; Male; Membrane Lipids/metabolism; Methylation; Phospholipids/metabolism; Rats; Rats, Inbred Strains; Receptors, GABA-A/metabolism; S-Adenosylmethionine; gamma-Aminobutyric Acid/pharmacology;

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