Article date: 1990/3/1
PubMed ID: 2158482
Journal name: Hormones and behavior (ISSN: 0018-506X)
The behavioral effects of GABA analogs were investigated to determine whether GABAergic neurotransmission is involved in the stress-induced inhibition of masculine sexual behaviors in rough-skinned newts (Taricha granulosa). Injections of bicuculline, a GABA antagonist, stimulated male sexual behaviors in a dose-dependent fashion, and the minimum effective dose was 40-fold less when administered centrally rather than systemically, suggesting a central nervous system site of action. Injections of muscimol, a GABA agonist, suppressed reproductive behaviors in male newts, and this inhibition lasted at least 5 hr and was proportional to the dose of muscimol administered. The inhibitory effects of muscimol on newt sexual behaviors could be reversed by a single 100-microgram ip injection of arginine vasotocin. The inhibitory effects of confinement stress or corticosterone (CS) injections on newt sexual behaviors were blocked by pretreatment of newts with mercaptopropionic acid, a blocker of GABA synthesis. As well, bicuculline prevented the inhibition of sexual behavior induced by CS injection. These results support the conclusion that, in a male amphibian, the GABAergic system is involved in the inhibitory mechanisms regulating sexual behaviors and that CS mediates the stress-induced inhibition of sexual behaviors through the GABAergic system.
Author List: Boyd S K, Moore F L
Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Receptors, GABA-A; gamma-Aminobutyric Acid;
Mesh terms: Animals; Arousal/physiology; Brain/physiology; Copulation/physiology; Exploratory Behavior/physiology; Female; Male; Motor Activity/physiology; Neural Inhibition/physiology; Receptors, GABA-A/physiology; Salamandridae/physiology; Seasons; Sexual Behavior, Animal/physiology; gamma-Aminobutyric Acid/physiology;