Enhancement in switching motor patterns following local application of the glutamate agonist AMPA into the cat caudate nucleus.

Article date: 1990/3/26

PubMed ID: 2160248

Journal name: Behavioural brain research (ISSN: 0166-4328)


The effect of caudate nucleus (CN)-injections of the glutamate agonist DL-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA), viz. an agonist of quisqualate receptors, on switching behaviour was investigated: first, cats had to switch from hanging with the forepaws on the bar to climbing on the bar; then, they had to switch to walking; finally, they had to switch to jumping off the bar. AMPA induced limb deficits, i.e. unilateral incorrect or absent placing of the fore- and/or hindlimb, in part of the tested cats; in the remainder of the tested animals AMPA reduced climbing time. Limb deficits were prevented by the broad-spectrum glutamate antagonist kynurenic acid (KYN) and by the selective NMDA antagonist D-2-amino-7-phosphono-heptanoate. In all cats AMPA increased the number of head movements as well as that of walking-restarts. These effects were counteracted only by KYN. These data show that part of the AMPA-induced effects were selectively mediated by quisqualate receptors. The present data are discussed in view of the role of the caudate nucleus in switching behaviour.

This document is available from: http://directlinks.cc/files/muscimol/2160248.pdf

Author List: Jaspers R M, de Vries T J, Cools A R

Publication Types: Journal Article

Substances mentioned in the article: Oxazoles; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Ibotenic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

Mesh terms: Animals; Brain Mapping; Cats; Caudate Nucleus/drug effects; Dominance, Cerebral/drug effects; Forelimb/innervation; Hindlimb/innervation; Ibotenic Acid/analogs & derivatives; Locomotion/drug effects; Male; Motor Activity/drug effects; Motor Skills/drug effects; Neurons/drug effects; Oxazoles/pharmacology; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter/drug effects; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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