Stress induced alterations in striatal GABAA receptor complex.

Article date: 1990/5/1

PubMed ID: 2161962

Journal name: Japanese journal of pharmacology (ISSN: 0021-5198)


The effect of cold-immobilized stress on the gamma-aminobutylic acid (GABA)/benzodiazepine (BZP) receptor complex in the rat striatum was examined. The stressful manipulation induced a significant decrease in the amount of [3H]muscimol binding sites in the striatal particulate fraction. On the other hand, [3H]flunitrazepam (FLN) binding and the enhancing effect of FLN or secobarbital on the [3H]muscimol binding to the striatal particulate fraction were not influenced by the stress treatment. These results suggest that cold-immobilized stress may selectively change GABAA receptor binding without altering BZP receptor binding as well as the functional coupling between GABAA and BZP receptors.

This document is available from: http://directlinks.cc/files/muscimol/2161962.pdf

Author List: Zhang M Y, Hashimoto T, Kuriyama K

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Receptors, GABA-A; Secobarbital; Muscimol; Flunitrazepam;

Mesh terms: Animals; Cold Temperature; Corpus Striatum/drug effects; Flunitrazepam/metabolism; Kinetics; Male; Muscimol/metabolism; Postural Balance/drug effects; Rats; Rats, Inbred Strains; Receptors, GABA-A/metabolism; Reflex/drug effects; Restraint, Physical; Secobarbital/pharmacology; Stress, Psychological/metabolism;

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