2169425

GABAB receptor-mediated contractile effects resistant to tetrodotoxin in isolated cat ileum.

Article date: 1990/6/21

PubMed ID: 2169425

Journal name: European journal of pharmacology (ISSN: 0014-2999)

ABSTRACT

The effects of gamma-aminobutyric acid (GABA) and GABAergic drugs were studied on longitudinal strips from cat terminal ileum prepared after removing the myenteric plexus. GABA and baclofen exerted concentration-dependent contractile effects. Muscimol was ineffective, and bicuculline did not antagonize the effect of GABA. The complete elimination of the neural input to the smooth muscle cells by tetrodotoxin failed to prevent the action of GABA and baclofen. Pharmacological analyses of the effects indicated the existence of GABAB receptors on the smooth muscle cells in the longitudinal layer of cat terminal ileum.

This document is available from: http://directlinks.cc/files/muscimol/2169425.pdf

Author List: Pencheva N, Venkova K, Radomirov R

Publication Types: Journal Article

Substances mentioned in the article: Receptors, GABA-A; Tetrodotoxin; gamma-Aminobutyric Acid; Baclofen; Bicuculline;

Mesh terms: Animals; Baclofen/pharmacology; Bicuculline/pharmacology; Cats; Drug Resistance; Ileum/drug effects; In Vitro Techniques; Male; Muscle Contraction/drug effects; Muscle Denervation; Muscle, Smooth/drug effects; Receptors, GABA-A/physiology; Tetrodotoxin/pharmacology; gamma-Aminobutyric Acid/pharmacology;

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