Article date: 1990/9/1
PubMed ID: 2173543
Journal name: Behavioral and neural biology (ISSN: 0163-1047)
Immediate post-training intraperitoneal injections of the GABA antagonist bicuculline (0.25 or 0.5 mg/kg) or of the GABA agonist muscimol (1.0 or 2.0 mg/kg) improved and impaired, respectively, retention of CD1 mice tested 24 h after training in a one-trial inhibitory avoidance task. Administration of bicuculline or muscimol prior to the retention test did not modify retention latencies of mice that had received either saline or the same drug immediately after training. These findings indicate that the effects of post-training administration of bicuculline and muscimol on retention are not state dependent and, thus, argue against a general state-dependency interpretation of the effects of post-training treatments affecting retention. The findings are consistent with previous evidence indicating that GABAergic drugs affect retention through influences on memory storage processes.
Author List: Castellano C, McGaugh J L
Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Receptors, GABA-A; Muscimol; Bicuculline;
Mesh terms: Animals; Arousal/drug effects; Avoidance Learning/drug effects; Bicuculline/pharmacology; Brain/drug effects; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Muscimol/pharmacology; Reaction Time/drug effects; Receptors, GABA-A/drug effects; Retention (Psychology)/drug effects;