2178036

NMDA and kainic acid receptors have a complementary distribution to AMPA receptors in the human cerebellum.

Article date: 1990/11/5

PubMed ID: 2178036

Journal name: Brain research (ISSN: 0006-8993)

ABSTRACT

The distributions of N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-S-methyl-4-isoxazole propionic acid (AMPA) and kainic acid (KA) receptors were determined in the human cerebellum using autoradiography. In contrast to the cerebral cortex, where KA receptors have a complementary distribution to NMDA and AMPA receptors, AMPA receptors were concentrated in the cerebellar molecular layer while NMDA and KA receptors were concentrated in the granular layer.

Author List: Jansen K L, Faull R L, Dragunow M

Publication Types: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Ibotenic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Kainic Acid;

Mesh terms: Aged; Autoradiography; Cerebellum/chemistry; Female; Humans; Ibotenic Acid/analogs & derivatives; Kainic Acid; Male; Middle Aged; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate/analysis; Receptors, Neurotransmitter/analysis; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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