Injections of muscimol into the paraventricular thalamic nucleus, but not mediodorsal thalamic nuclei, induce feeding in rats.

Article date: 2013/5/31

PubMed ID: 2224500

Journal name: Brain research (ISSN: 1872-6240)

DOI: S0006-8993(12)01700-3


The paraventricular thalamic nucleus (PVT) is a component of the midline thalamic group that is interconnected with several brain regions known to play important roles in the control of food intake, including the lateral hypothalamus and nucleus accumbens shell, suggesting that the PVT itself may be involved in mediating feeding behavior. In the current study, we examined whether inhibition of cells in the PVT with the GABA(A) agonist muscimol could alter food intake in non-deprived rats. To control for possible spread of the drug, we also observed food intake after injections of muscimol into the overlying ventricle or laterally adjacent mediodorsal thalamic nuclei (MD). We found that muscimol injections into the central PVT dose-dependently increased food intake. In contrast, intra-MD injections of muscimol resulted in a potent dose-dependent suppression of food intake, while those into the overlying ventricle had no effect. These results support the proposal that the PVT is a component of the neural circuitry controlling feeding behavior.

Author List: Stratford Thomas R, Wirtshafter David

Publication Types: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Article Date: 2012/10/27

Substances mentioned in the article: GABA-A Receptor Agonists; Muscimol;

Mesh terms: Animals; Dose-Response Relationship, Drug; Eating/drug effects; Feeding Behavior/drug effects; GABA-A Receptor Agonists/administration & dosage; Injections, Intraventricular; Male; Mediodorsal Thalamic Nucleus/physiology; Microinjections; Muscimol/administration & dosage; Paraventricular Hypothalamic Nucleus/physiology; Rats; Rats, Sprague-Dawley; Satiation/physiology; Third Ventricle;

Citations: - 3191403

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