2250581

Effects of muscimol and flurazepam on the sleep EEG in the rat.

Article date: 1990/1/1

PubMed ID: 2250581

Journal name: Life sciences (ISSN: 0024-3205)

ABSTRACT

In order to assess the possible role of GABA receptor function in the hypnotic property of benzodiazepines, we have examined the sleep EEG in rats given the GABA agonist muscimol, alone and in combination with flurazepam. Muscimol 0.05 and 0.1 mg/kg IP failed to alter sleep latency or total sleep time, and did not interact with the sleep-enhancing properties of flurazepam 20 mg/kg IP. These observations, in conjunction with a previous study of bicuculline, suggest that the hypnotic property of benzodiazepines may not be mediated by alteration of GABAergic activity.

This document is available from: http://directlinks.cc/files/muscimol/2250581.pdf

Author List: Mendelson W B, Martin J V

Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Substances mentioned in the article: Muscimol; Flurazepam;

Mesh terms: Animals; Electroencephalography; Flurazepam/pharmacology; Male; Muscimol/pharmacology; Rats; Rats, Inbred Strains; Sleep/physiology;

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