Article date: 1990/1/1
PubMed ID: 2250581
Journal name: Life sciences (ISSN: 0024-3205)
In order to assess the possible role of GABA receptor function in the hypnotic property of benzodiazepines, we have examined the sleep EEG in rats given the GABA agonist muscimol, alone and in combination with flurazepam. Muscimol 0.05 and 0.1 mg/kg IP failed to alter sleep latency or total sleep time, and did not interact with the sleep-enhancing properties of flurazepam 20 mg/kg IP. These observations, in conjunction with a previous study of bicuculline, suggest that the hypnotic property of benzodiazepines may not be mediated by alteration of GABAergic activity.
Author List: Mendelson W B, Martin J V
Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Substances mentioned in the article: Muscimol; Flurazepam;
Mesh terms: Animals; Electroencephalography; Flurazepam/pharmacology; Male; Muscimol/pharmacology; Rats; Rats, Inbred Strains; Sleep/physiology;