Article date: 1990/9/17
PubMed ID: 2253039
Journal name: Brain research (ISSN: 0006-8993)
We compared the effects on spatial learning of an ibotenic acid lesion of the nucleus basalis magnocellularis (NBM), a 5, 7-dihydroxytryptamine lesion of the raphe dorsalis (RD) and a combined NBM and RD lesion. The RD lesion reduced serotonin levels, and the NBM lesion reduced cholineacetyltransferase (ChAT) activity in the cortex. Although RD lesions alone did not affect spatial learning in the water-maze, the lesion aggravated the spatial navigation deficit produced by NMB lesioning. The current results suggest a functional interaction between the RD and NBM in spatial navigation.
Author List: Riekkinen P, Sirviö J, Riekkinen P
Publication Types: Journal Article
Substances mentioned in the article: Ibotenic Acid;
Mesh terms: Animals; Escape Reaction; Ibotenic Acid; Learning; Male; Olivary Nucleus/physiology; Raphe Nuclei/physiology; Rats; Rats, Inbred Strains; Reference Values; Space Perception; Stereotaxic Techniques;