2253741

[The neurochemical characteristics of the effect of morphine and pentapeptide FK 33-824 on cerebral cortical excitability].

Article date: 1990/9/1

PubMed ID: 2253741

Journal name: Farmakologiia i toksikologiia (ISSN: 0014-8318)

ABSTRACT

GABA-stimulating agents (muscimol, depakine, aminohydroxyacetic acid), serotonin stimulants (5-hydroxytryptophan, fluoxetine), catecholaminergic stimulants (L-DOPA, apomorphine) and a cholinergic inhibitor (hemicholinium-3) of the brain were found to enhance the inhibitory effect of morphine and pentapeptide FK 33-824 on the cortical excitability of free-moving cats. GABA-negative agents (thiosemicarbazide, bicuculline, picrotoxin), serotonin-negative agents (p-chlorophenylalanine, methysergide), catecholaminergic inhibitors (6-hydroxydopamine, alpha-methyl-p-tyrosine) and cholinergic stimulant (physostigmine) of the brain appeared to decrease the effects of morphine and pentapeptide FK 33-824 on the excitability of the cortex. beta-adrenoceptor blocker propranolol decreased the effects of morphine and pentapeptide FK 33-824 on the cortical excitability, whereas alpha-adrenoblockers (phentolamine, phenoxybenzamine and yochimbine) exerted no effect on their action.

Author List: Fisenko V P

Publication Types: English Abstract; Journal Article

Substances mentioned in the article: D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Morphine;

Mesh terms: Animals; Cats; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin/pharmacology; Drug Interactions; Electric Stimulation; Morphine/pharmacology; Somatosensory Cortex/drug effects; Time Factors;

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