226375

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226375 [2018/11/22 21:16] (current)
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 +====== Presynaptic GABA autoreceptors on GABAergic nerve endings of the rat substantia nigra.======
 +
 +** Article date:** 1979/8/1
 +~~META:date created = 1979-08-01~~
 +
 +** PubMed ID: 226375 **
 +
 +** Journal name: European journal of pharmacology (ISSN: 0014-2999) **
 +
 +** ABSTRACT **
 +
 +The release of 3H-GABA evoked by exposure to 30 mM potassium during 1 min was found to calcium independent in the rat occipital cortex and calcium dependent in the substantia nigra. Exposure to either muscimol 1 microM or GABA 1 microM inhibited the potassium-evoked release of 3H-GABA from the substantia nigra but not from the occipital cortex. The inhibitory effect of muscimol 1 microM on the potassium-evoked release of 3H-GABA from the substantia nigra was significantly antagonized by picrotoxin 10 microM. Exposure to either 10 or 100 microM pricrotoxin alone did not affect the potassium-evoked release of 3H-GABA. These results are compatible with the presence of a negative feedback mechanism in bagaergic nerve terminals of the rat substantia nigra which is mediated by presynaptic GABA autoreceptors. In addition, these results emphasize the importance of the calcium-dependent nature of the release of the neurotransmitter for demonstrating the modulation of transmitter release through presynaptic receptors.
 +
 +===== ===== 
 +
 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​226375.pdf}}
 +
 +Author List: Arbilla S, Kamal L, Langer S Z
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Receptors, Cell Surface; Picrotoxin; Muscimol; gamma-Aminobutyric Acid; Potassium; Calcium; ​
 +
 +Mesh terms: Animals; Calcium/​pharmacology;​ Cerebral Cortex/​metabolism;​ In Vitro Techniques; Male; Muscimol/​pharmacology;​ Nerve Endings/​physiology;​ Picrotoxin/​pharmacology;​ Potassium/​pharmacology;​ Rats; Receptors, Cell Surface/​physiology;​ Substantia Nigra/​metabolism;​ gamma-Aminobutyric Acid/​metabolism; ​
 +
 +{{tag> Receptors,​_Cell_Surface Potassium gamma-Aminobutyric_Acid Picrotoxin Muscimol Calcium }}
 +
 +{{keywords>​ Receptors, Cell Surface, Potassium, gamma-Aminobutyric Acid, Picrotoxin, Muscimol, Calcium}}
 +
  
226375.txt · Last modified: 2018/11/22 21:16 (external edit)