2265972

Habenula as a relay in the descending pathway from nucleus accumbens to periaqueductal grey subserving antinociception.

Article date: 1990/10/1

PubMed ID: 2265972

Journal name: The International journal of neuroscience (ISSN: 0020-7454)

ABSTRACT

This study explored the possibility of a relay at habenula for the descending neural pathway of antinociception. The latency of the escape response elicited by radiant heat on the snout of the rabbit was taken as index of nociception. (1) Microinjection of 20 micrograms of morphine into nucleus accumbens resulted in a one-fold increase in nociceptive threshold 20-40 min after the injection. This effect of morphine was markedly attenuated by naloxone or met-enkephalin antiserum administered to the nucleus habenula, suggesting that the release of met-enkephalin in habenula is essential for the antinociception induced by morphine injected into nucleus accumbens. (2) Injection of 10 micrograms of morphine into habenula produced a significant increase in escape response latency 20-40 min after the injection. This antinociceptive effect of morphine was attenuated by naloxone or muscimol, and enhanced by bicuculline methochloride administered to periaqueductal grey, suggesting that morphine may act on habenula to activate a descending neural pathway extending to periaqueductal grey to induce an antinociceptive effect, which seems to utilize endogenous opioid peptides and gamma-aminobutyric acid as its mediators. Taking together, the results suggest that habenula is an important relay in the descending neural pathway from nucleus accumbens to periaqueductal grey subserving antinociception.

This document is available from: http://directlinks.cc/files/muscimol/2265972.pdf

Author List: Yu L C, Han J S

Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Immune Sera; Muscimol; Naloxone; Enkephalin, Methionine; Morphine; bicuculline methochloride; Bicuculline;

Mesh terms: Animals; Bicuculline/analogs & derivatives; Efferent Pathways/physiology; Enkephalin, Methionine/immunology; Immune Sera/immunology; Injections; Morphine/pharmacology; Muscimol/pharmacology; Naloxone/pharmacology; Nociceptors/drug effects; Nucleus Accumbens/physiology; Periaqueductal Gray/physiology; Rabbits; Thalamic Nuclei/physiology;

2265972.txt ยท Last modified: 2018/11/22 21:16 (external edit)