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227532 [2018/11/22 21:16] (current)
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 +====== The localization of receptor binding sites in the substantia nigra and striatum of the rat.======
 +
 +** Article date:** 1979/11/16
 +~~META:date created = 1979-11-16~~
 +
 +** PubMed ID: 227532 **
 +
 +** Journal name: Brain research (ISSN: 0006-8993) **
 +
 +** ABSTRACT **
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 +Neurotransmitter receptor binding of 5 ligands was examined in the striatum, substantia nigra (SN) and frontal cortex of rats which had received either unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal pathway (NSP) or unilateral kainic acid lesions of the striatum. 6-OHDA lesions of the NSP significantly reduced [3H]dihydroalprenolol ([3H]DHA) and [3H]naloxone ([3H]Nal) binding by 31% and 28% respectively,​ in the denervated striatum compared to the contralateral side. Scatchard analysis revealed that the alteration in [3H]DHA binding was not due to a change in the affinity of the beta-adrenergic receptor for [3H]DHA. In marked contrast to these changes in the striatum, destruction of the NSP resulted in a significant increase in [3H]DHA and [3H]Nal binding by 44% and 26%, respectively,​ in the frontal cortex of the lesioned compared to the control side. 6-OHDA lesions in the NSP did not alter striatal receptor binding for [3H]quinuclidinyl benzilate ([3H]QNB), [3H]muscimol ([3H]Mus) or [3H]flunitrazepam ([3H]Flu). Similarily, intrastriatal kainic acid injections did not alter striatal receptor binding for [3H]Nal, [3H]Flu or [3H]Mus. Of the various receptor densities measured in the SN after the above lesions the only alteration observed was a 43% increase in [3H]Flu binding following 6-OHDA lesions of the NSP. Scatchard analysis indicated no change in the affinity of the benzodiazepine receptor for [3H]Flu. 6-OHDA lesions of the NSP did not alter [13H]QNB or [3H]Nal binding in the SN. Striatal kainic acid lesions did not alter nigral [3H]QNB or [3H]Flu binding. The results are discussed in terms of neurotransmitter localization and plasticity within the striatum, SN and frontal cortex.
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 +===== ===== 
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 +{{gview 100%,​450px>​ http://​directlinks.cc/​files/​muscimol/​227532.pdf}}
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 +Author List: Reisine T D, Nagy J I, Beaumont K, Fibiger H C, Yamamura H I
 +
 +Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
 +
 +Substances mentioned in the article: Hydroxydopamines;​ Receptors, Adrenergic, beta; Receptors, Cholinergic;​ Receptors, Dopamine; Receptors, Neurotransmitter;​ Receptors, Opioid; Muscimol; Naloxone; gamma-Aminobutyric Acid; Dihydroalprenolol;​ Quinuclidinyl Benzilate; Fluphenazine;​ Kainic Acid; 
 +
 +Mesh terms: Animals; Brain Mapping; Corpus Striatum/​drug effects; Dihydroalprenolol/​metabolism;​ Fluphenazine/​metabolism;​ Hydroxydopamines/​pharmacology;​ Kainic Acid/​pharmacology;​ Male; Muscimol/​metabolism;​ Naloxone/​metabolism;​ Neural Pathways/​drug effects; Neurons/​drug effects; Quinuclidinyl Benzilate/​metabolism;​ Rats; Receptors, Adrenergic, beta/​metabolism;​ Receptors, Cholinergic/​metabolism;​ Receptors, Dopamine/​drug effects; Receptors, Neurotransmitter/​metabolism;​ Receptors, Opioid/​metabolism;​ Substantia Nigra/drug effects; gamma-Aminobutyric Acid/​metabolism; ​
 +
 +{{tag> Receptors,​_Neurotransmitter Receptors,​_Adrenergic,​_beta Dihydroalprenolol Fluphenazine Kainic_Acid Quinuclidinyl_Benzilate Receptors,​_Dopamine Receptors,​_Opioid gamma-Aminobutyric_Acid Hydroxydopamines Muscimol Receptors,​_Cholinergic Naloxone }}
 +
 +{{keywords>​ Receptors, Neurotransmitter,​ Receptors, Adrenergic, beta, Dihydroalprenolol,​ Fluphenazine,​ Kainic Acid, Quinuclidinyl Benzilate, Receptors, Dopamine, Receptors, Opioid, gamma-Aminobutyric Acid, Hydroxydopamines,​ Muscimol, Receptors, Cholinergic,​ Naloxone}}
 +
  
227532.txt · Last modified: 2018/11/22 21:16 (external edit)