Changes in succinate dehydrogenase activity of rats after intraventricular injections of GABA, muscimol and picrotoxin.

Article date: 1990/9/1

PubMed ID: 2279777

Journal name: Indian journal of experimental biology (ISSN: 0019-5189)


Effects of intraventricular injections of GABA, and a GABA agonist, muscimol and an antagonist, picrotoxin on succinate dehydrogenase (SDH) enzyme activity in plasma and a few hypothalamic nuclei of brain of rats have been investigated using biochemical, histochemical and cytophotometric techniques. Results show that SDH decreased by GABA and muscimol treatment, and increased after picrotoxin injection. From the above findings, it is apparent that GABA, muscimol and picrotoxin influence SDH activity of plasma and hypothalamic nuclei.

Author List: Rattan A K, Dhatt R K, Mangat H K

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Picrotoxin; Muscimol; gamma-Aminobutyric Acid; Succinate Dehydrogenase;

Mesh terms: Animals; Injections, Intraventricular; Male; Muscimol/administration & dosage; Picrotoxin/administration & dosage; Rats; Rats, Inbred Strains; Succinate Dehydrogenase/metabolism; gamma-Aminobutyric Acid/administration & dosage;

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