Mediodorsal thalamic lesions and Pavlovian conditioning of heart rate and eyeblink responses in the rabbit.

Article date: 1990/12/1

PubMed ID: 2285490

Journal name: Behavioral neuroscience (ISSN: 0735-7044)


Rabbits received ibotenic acid lesions of the mediodorsal nucleus of the thalamus (MD) or sham lesions. These animals were compared on 4 sessions of Pavlovian eyeblink and heart rate conditioning, in which a tone was the conditioned stimulus and a paraorbital electrical shock was the unconditioned stimulus. Lesions of MD retarded acquisition of the eyeblink conditioned response and abolished the late-occurring tachycardiac component of the heart rate conditioned response. The data are compatible with previous experiments suggesting that MD participates in the sympathetic control associated with somatomotor learning.

Author List: Buchanan S L, Thompson R H

Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Substances mentioned in the article:

Mesh terms: Animals; Arousal/physiology; Attention/physiology; Brain Mapping; Conditioning, Classical/physiology; Conditioning, Eyelid/physiology; Frontal Lobe/physiology; Heart Rate/physiology; Neural Pathways/physiology; Neurons/physiology; Rabbits; Thalamic Nuclei/physiology;

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