2305257

An ATP-sensitive potassium channel blocker abolishes the potentiating effect of morphine on the bicuculline-induced convulsion in mice.

Article date: 1993/1/1

PubMed ID: 2305257

Journal name: Psychopharmacology (ISSN: 0033-3158)

ABSTRACT

ICV bicuculline, a selective GABAA antagonist, dose-dependently induced clonic-tonic convulsions in mice. Coadministration of ICV morphine (mu opioid agonist) significantly potentiated ICV bicuculline-induced convulsions, and this effect of morphine was completely blocked by pretreatment with beta-funaltrexamine (beta-FNA), a mu antagonist. ICV glibenclamide, a selective ATP-sensitive potassium (KATP) channel blocker, at a dose which alone did not affect the convulsive threshold of bicuculline, was capable of blocking the exacerbation of ICV bicuculline-induced convulsions by morphine. The present data further suggest that KATP channels may play a tonic regulatory role in the potentiative effect of morphine on ICV bicuculline-induced convulsions.

Author List: Narita M, Takahashi Y, Suzuki T, Misawa M, Nagase H

Publication Types: Journal Article

Substances mentioned in the article: Potassium Channels; Muscimol; Morphine; Adenosine Triphosphate; Glyburide; Bicuculline;

Mesh terms: Adenosine Triphosphate/pharmacology; Animals; Behavior, Animal/drug effects; Bicuculline/administration & dosage; Epilepsy, Tonic-Clonic/chemically induced; Glyburide/administration & dosage; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine/administration & dosage; Muscimol/pharmacology; Potassium Channels/drug effects;

Citations: - 3982215

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