Article date: 1990/2/5
PubMed ID: 2306621
Journal name: Brain research (ISSN: 0006-8993)
This study demonstrates that the central medial intralaminar nucleus (CeM) controls generalized seizure threshold and expression, and that these functions are under gamma-aminobutyric acid (GABA)ergic control, with significant differences between receptor subtypes. Injections of the GABAA-agonist piperidine-4-sulfonic acid and the GABAB-agonist (-)baclofen in the CeM markedly facilitated myoclonic and clonic seizures, but had different effects on tonic seizures. These results are best explained by the concept that the CeM is not a site of seizure origin or spread but rather regulates other structures involved in seizures.
Author List: Miller J W, Ferrendelli J A
Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Muscimol; Baclofen; Bicuculline;
Mesh terms: Animals; Baclofen/pharmacology; Bicuculline; Dose-Response Relationship, Drug; Female; Muscimol/pharmacology; Rats; Rats, Inbred Strains; Seizures/chemically induced; Thalamic Nuclei/drug effects;