High-affinity binding of [3H]muscimol to subcellular particles of a neurone-enriched culture of embryonic rat brain.

Article date: 1979/10/1

PubMed ID: 231232

Journal name: Neuroscience letters (ISSN: 0304-3940)


High-affinity, Na+-independent binding of [3H]muscimol (KB approximately equal to 1.6 x 10(-8) M; Bmax approximately equal to 0.14 nmol/g pellet) occurred to a frozen-thawed particulate fraction of 74-h-old neurone-enriched cultures prepared from the cerebra of 12-13-day-old rat embryos. This finding provides evidence that GABA-receptors exist on cultured neurones which contain only a few synaptic connections.

This document is available from: http://directlinks.cc/files/muscimol/231232.pdf

Author List: DeFeudis F V, Ossola L, Schmitt G, Mandel P

Publication Types: Journal Article

Substances mentioned in the article: Oxazoles; Receptors, Neurotransmitter; Muscimol; gamma-Aminobutyric Acid;

Mesh terms: Animals; Brain/embryology; Brain Chemistry; Culture Techniques; Muscimol/metabolism; Oxazoles/metabolism; Rats; Receptors, Neurotransmitter/analysis; Subcellular Fractions/metabolism; gamma-Aminobutyric Acid/metabolism;

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