Habituation and retention of the head-shake response: lack of impairment by nucleus basalis magnocellularis lesions.

Article date: 1990/1/1

PubMed ID: 2315354

Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)


Bilateral ibotenic acid lesions of the nucleus basalis magnocellularis (NBM) were examined on the habituation and retention of the head-shake response (HSR). HSR, a rapid, stereotyped rotation of the head about a front-to-rear axis, was elicited by a stream of mildly pressurized air directed at the ear in Fischer 344 rats. HSR training consisted of 40 stimulated trials followed by a 30-min retention test of 20 stimulated trials. Stimulus duration was 15 sec per trial with a 15-sec intertrial interval. Frontal cortex choline acetyltransferase was reduced by 22% in the NBM-lesioned group compared to the controls. The NBM-lesioned rats and the controls were not significantly different on either frequency or latency measures of HSR habituation or retention. The results do not support a role for cortical cholinergic mediation of the HSR.

Author List: Dokla C P, Parker S C, Thal L J

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Choline O-Acetyltransferase;

Mesh terms: Animals; Choline O-Acetyltransferase/metabolism; Habituation, Psychophysiologic/physiology; Head; Male; Memory/physiology; Olivary Nucleus/physiology; Rats; Rats, Inbred F344; Retention (Psychology)/physiology; Stereotyped Behavior/physiology;

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