Nucleus basalis lesions fail to induce senile plaques in the rat.

Article date: 1990/4/1

PubMed ID: 2318291

Journal name: Experimental neurology (ISSN: 0014-4886)


Fourteen months after receiving bilateral ibotenic acid lesions of the nucleus basalis magnocellaris (NBM), male rats demonstrated impairment in spatial learning in a water maze task, increased incidence of high voltage spindles, and significant depletion of cortical choline acetyltransferase (ChAT) activity. Histological evaluation revealed decreased acetylcholinesterase (AChE) staining but no plaque-like structures in the cortex.

Author List: Thal L J, Mandel R J, Terry R D, Buzsaki G, Gage F H

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Oxazoles; Ibotenic Acid; Choline O-Acetyltransferase; Acetylcholinesterase;

Mesh terms: Acetylcholinesterase/metabolism; Alzheimer Disease; Animals; Basal Ganglia/anatomy & histology; Choline O-Acetyltransferase/metabolism; Disease Models, Animal; Electroencephalography; Ibotenic Acid/pharmacology; Learning/physiology; Male; Oxazoles/pharmacology; Rats; Rats, Inbred F344;

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