Ibotenic acid lesions of the basal forebrain cholinergic system retard amygdala kindling.

Article date: 1990/5/1

PubMed ID: 2349263

Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)


The effect of ibotenate lesions of septum and substantia innominata on electrical kindling of the amygdala was investigated in rats. The lesions significantly retarded kindling in the absence of a change in initial seizure sensitivity. This suggests that cholinergic neurotransmission can contribute to, but is not crucial for, amygdala kindling, and that a major component of the cholinergic circuitry involved in amygdala kindling may originate in the septum or substantia innominata or both.

Author List: Cain D P, Stewart D J

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Ibotenic Acid;

Mesh terms: Amygdala/physiology; Animals; Cholinergic Fibers/drug effects; Electric Stimulation; Ibotenic Acid/toxicity; Kindling, Neurologic; Male; Rats;

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