Article date: 1990/5/1
PubMed ID: 2349263
Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)
The effect of ibotenate lesions of septum and substantia innominata on electrical kindling of the amygdala was investigated in rats. The lesions significantly retarded kindling in the absence of a change in initial seizure sensitivity. This suggests that cholinergic neurotransmission can contribute to, but is not crucial for, amygdala kindling, and that a major component of the cholinergic circuitry involved in amygdala kindling may originate in the septum or substantia innominata or both.
Author List: Cain D P, Stewart D J
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Ibotenic Acid;
Mesh terms: Amygdala/physiology; Animals; Cholinergic Fibers/drug effects; Electric Stimulation; Ibotenic Acid/toxicity; Kindling, Neurologic; Male; Rats;